{"id":38,"date":"2017-07-17T09:02:39","date_gmt":"2017-07-17T09:02:39","guid":{"rendered":"https:\/\/synbiolab.bilkent.edu.tr\/?page_id=38"},"modified":"2022-11-15T12:35:47","modified_gmt":"2022-11-15T09:35:47","slug":"news","status":"publish","type":"page","link":"https:\/\/synbiolab.bilkent.edu.tr\/news\/","title":{"rendered":"News"},"content":{"rendered":"
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Our lab member Ahmet H\u0131n\u00e7er won the 2nd Best oral presentation award for his work to develop an innovative synthetic mRNA platform for Vaccine and Drug development in <\/span>#4thVaccinology<\/a><\/span> Congress.<\/span><\/div>\n
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We developed a genetically engineered protein nanomaterial using <\/span>#syntheticbiology<\/a><\/span> tools to capture viral particles, including <\/span>Sars-CoV2<\/a><\/span>. It is highlighted on the cover of Advanced Materials Interfaces<\/span><\/p>\n

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We are happy to see our lab member Anooshay Khan successfully defended her MSc thesis and graduated from Bilkent U. Neuroscience program. IN her thesis she worked on understanding the inhibition mechanism of protein aggregates in Huntington’s disease using peptide therapeutics.<\/p>\n

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Dr. Seker\u00a0<\/span>and visiting Dr. Esra Yuca have prepared a book chapter on “how to monitor bacterial amyloid formation, and biofilm assembly in real time”. You may reach the chapter from here: <\/span>https:\/\/<\/span>link.springer.com\/protocol\/10.1007\/978-1-0716-2529-3_3<\/span><\/a><\/div>\n
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04\/08\/2022<\/p>\n

A new book chapter is published by our lab “Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine” , our chapter is entitled “Design and construction of protein and peptide-basedself-assembled nanostructures\u201d https:\/\/www.sciencedirect.com\/book\/9780323909846\/design-principle-and-application-of-self-assembled-nanobiomaterials-in-biology-and-medicine<\/p>\n<\/div>\n

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Our paper “Engineered Bacteria with Genetic Circuits Accumulating Nanomagnets as MRI Contrast Agents” is published in Small and highlighted in the inner cover. https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/smll.202200537<\/div>\n
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18\/01\/2022<\/p>\n<\/div>\n

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Developing a Sars-CoV-2 blocking lectin protein is out, highlighted from the front cover of ACS Infectious Diseases
\n<\/span>The potency of GRFT proteins on blocking Wuhan strain, Delta and Omicron variants without causing an immune response <\/span>https:\/\/<\/span>pubs.acs.org\/doi\/10.1021\/acsinfecdis.2c00006<\/span><\/a><\/div>\n
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The textbook “New Frontiers and Applications of Synthetic Biology” is now out, our lab has contributed with two chapters: <\/span><\/div>\n
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  • Chapter 17 – Design of synthetic biological devices for detection and targeting human diseases<\/span><\/li>\n
  • Chapter 22 – Design and applications of self-assembled soft living materials using synthetic biology<\/li>\n<\/ul>\n<\/div>\n
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    12\/01\/2022<\/div>\n
    Our PI, has been awarded the “T\u00dcBA COVID-19 <\/span>Global Outbreak First Prize” for our work on the <\/span>“Development of RNA Switch Systems for SARS-COV-2 Diagnosis\u201d<\/span><\/div>\n
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    09\/09\/2021<\/p>\n

    G\u00f6k\u00e7e <\/span> has successfully defended her MSc thesis: “Engineered Biofilm Proteins For Antibiotic Degradation and Sars-Cov-2 Capture”. Congrats G\u00f6k\u00e7e!\u00a0<\/span>She engineered biofilm backbones as modular molecular systems. She demonstrated how to use this system\u00a0to capture Sars-CoV-2 virus for sample concentrations by genetically fusing GRFT protein, and also by fusing an enzyme she managed to show how we can degrade antibiotics with help of genetically fused enzymes.\u00a0Her work is going to be part of two papers and patent applications. She’s going to continue with us as a PhD student. Good luck G\u00f6k\u00e7e!<\/span><\/p>\n

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    28\/05\/2021<\/p>\n

    Eray has successfully defended his masters thesis. He has re-engineered the glycosylation pathway in E. coli to create physically and chemically more stable proteins\/enzymes for biotech drugs. He is going to pursue a PhD at the Technical University of Denmark. Congratulations and good luck Eray.<\/p>\n

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    11\/02\/2021<\/p>\n

    Today we celebrated the\u00a0International Day of Women and Girls in Science.<\/p>\n

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    28\/01\/2021<\/p>\n

    Ebru Kehribar has successfully defended her PhD thesis: “Microbial Amyloids as Functional Biomaterials” with success. Congrats Dr. Ebru Kehribar! We are happy to announce that she will continue to work with us at UNAM as a postdoc and as a researcher at Synbiotik Biotechnology (where she’s also a co-founder). We wish great success to Dr. Ebru Kehribar in her future endeavours!<\/p>\n

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    13\/12\/2020<\/p>\n

    Our PI recently gave an interview (in Turkish) to Habert\u00fcrk about our ongoing COVID-19 research:<\/p>\n

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    16\/12\/2020<\/p>\n

    B\u00fc\u015fra Merve K\u0131rpat has successfully defended her master thesis: “Genetically programmed engineered cells for Biomaterial synthesis”.\u00a0 She will pursue her PhD studies at the University of Freiburg in Germany. Good Luck B\u00fc\u015fra!<\/p>\n

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    14\/12\/2020<\/p>\n

    S\u0131la K\u00f6se has successfully defended her master thesis: “Multiplexed Cell-Based Diagnostic Devices for Detection of Kidney Disease Pathological Markers”.\u00a0 She will pursue her PhD studies at the University of Konstanz in Germany. Good Luck S\u0131la!<\/p>\n

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    31\/07\/2021<\/p>\n

    Our PI recently gave an interview (in Turkish) to CNN Turk about our COVID-19 detection kit:<\/p>\n

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    Our work on creating a Toehold based Covid-19 testing kit has been uploaded to the preprint server medRxiv:
    \n    SARS-CoV-2 detection with de novo designed synthetic riboregulators<\/a><\/p>\n

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    28\/07\/2020<\/p>\n

    Our lab at UNAM was visited by the head of T\u00fcbitak: Prof. Dr. Hasan Mandal. We updated him on the recent developments on our COVID-19 testing kit.<\/p>\n

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    Prof. Dr. Hasan Mandal’s tweet about his visit to our lab can be seen below:<\/p>\n

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    24\/07\/2020<\/p>\n

    Behide Saltepe has successfully defended her PhD thesis: “Synthetic Genetic Circuits to Monitor Nanomaterial Triggered Toxicity” with success. Congrats Dr. Behide Saltepe!\u00a0She will soon be working as a postdoc in the UK. We wish great success to Dr. Behide Saltepe in her future endeavours!<\/p>\n

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    25\/06\/2020<\/p>\n

    Our lab at UNAM was visited by the Turkish minister of industry and technology: Mustafa Varank. We updated him on our COVID-19 research.<\/p>\n

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    After his visit, the minister tweeted about his visit to our lab:<\/p>\n

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    26\/04\/2021<\/p>\n

    We had our annual Synthetic Biology Day event with multiple speakers from around the world, covering various topics from helping the environment to developing new treatments to fight diseases.<\/p>\n

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    01\/04\/2021<\/p>\n

    Our joint work with Prof. Dr. Aykut \u00d6zkul<\/a> (Ankara University Institute of Biotechnology) on developing new treatments for COVID-19 has recently been covered by the Turkish media.
    \nAnadolu Ajans\u0131 (Turkish):\u00a0    T\u00fcrk bilim insanlar\u0131 Kovid-19’a kar\u015f\u0131 yeni nesil ila\u00e7 i\u00e7in \u00e7al\u0131\u015f\u0131yor<\/a><\/p>\n

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    More of our recent work on developing treatments for COVID – 19 has been covered by the media:<\/p>\n

    Bilkent News: Bilkent Researchers Work to Develop a Next-Generation Drug for Use Against COVID-19<\/a><\/p>\n

    Sabah Daily News: Scientists in Turkey developing drug that prevents COVID-19 multiplication in humans<\/a><\/p>\n

    BBC News (Turkish): Koronavir\u00fcs a\u015f\u0131s\u0131n\u0131n bulunmas\u0131 neden uzun s\u00fcr\u00fcyor?<\/a><\/p>\n

    Yeni \u015eafak News: Turkey\u2019s scientists to produce coronavirus cure within 6 months<\/a><\/p>\n

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    23\/01\/2020<\/p>\n

    Elif\u00a0has successfully defended her master thesis: “Peptide Drug Discovery for Pathogeneic Amyloids”.\u00a0 We are happy that Elif will continue her PhD studies with us.\u00a0Congrats Elif!
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    05\/10\/2019<\/p>\n

    Our work on \u00a0living sensor to detect\/ report toxicity in real-time \u00a0in \u00a0ACS Synthetic Biology<\/strong> :<\/p>\n

    “Genetic Circuits To Detect Nanomaterial Triggered Toxicity through Engineered Heat Shock Response Mechanism”<\/p>\n

    https:\/\/pubs.acs.org\/doi\/10.1021\/acssynbio.9b00291<\/a><\/p>\n

    co-authored by Behide Saltepe, Eray Ula\u015f Bozkurt, Nedim Hac\u0131osmano\u011flu, Congrats !<\/p>\n

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    10\/10\/2019<\/p>\n

    Anooshay (Neuroscience Grad program), Eray (MSN Grad Program), and Murat (MSN Grad Program) joined our research group. Murat will pursue his PhD with us for the applications of Control Theory on Synthetic Biological systems, Anooshay will work on neurodegenerative disease proteins, and Eray will be focused on living therapeutics systems. Welcome guys, wish you a happy and productive research time at SBL !<\/p>\n

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    26\/09\/2019<\/p>\n

    Our work on programming amyloid patterning using genetic logics gates is highlighted on the cover of Advanced Materials<\/strong> :<\/p>\n

    “Genetic Logic Gates Enable Patterning of Bacterial Nanofibers”<\/p>\n

    https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adma.201902888<\/a><\/p>\n

    co-authored by Ebuzer Kalyoncu, Recep Erdem Ahan, Cemile Elif \u00d6z\u00e7elik, Congrats !<\/p>\n

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    14\/09\/2019<\/p>\n

    Efe \u00a0has successfully presented his master thesis work on a synthetic glycosylation pathway for protein materials. He designed a new generation of protein materials.<\/p>\n

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    06\/09\/2019<\/p>\n

    \u00d6zge has successfully defended her master thesis “A Peptide Based Drug Discovery Platform Targeting Neurodegenerative Diseases”. She completed construction of a yeast display library, genome edited cells expressing Huntingtin, AB peptides and a-synuclein. Congrats \u00d6zge!<\/p>\n

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    Our work on an engineered protein secretion machinery is highlighted on the cover of ACS Synthetic Biology<\/p>\n

    ” A Self-Actuated Cellular Protein Delivery Machine”<\/p>\n

    https:\/\/pubs.acs.org\/doi\/10.1021\/acssynbio.9b00062<\/p>\n

    co-authored by Recep Erdem Ahan, Behide Saltepe and B\u00fc\u015fra Merve K\u0131rpat, Congrats !<\/p>\n

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    19\/08\/2019<\/p>\n

    Nedim\u00a0<\/span>has defended his master thesis with success, he developed engineered bacteria those can sense changes in glucose level and secrete necessary biomolecules to control glucose level. Congrats Nedim !<\/span><\/p>\n

    He will pursuing his PhD\u00a0<\/span> with us, we are thrilled !\u00a0<\/span><\/p>\n

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    05\/08\/2019<\/p>\n

    Elif Duman defended her PhD thesis with success, Congrats Dr. Elif Duman. She will be working as staff scientist Matriks Biotek, we wish great success to Dr. Elif Duman in her future endeavours!<\/p>\n

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    Our work on catalytic biofilm secreting synthetic genetic circuits is highlighted on the cover of ChemBioChem <\/strong><\/p>\n

    ”\u00a0Cellular Biocatalysts Using Synthetic Genetic Circuits for Prolonged and Durable Enzymatic Activity”<\/p>\n

    https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/cbic.201800767<\/a><\/p>\n

    co-authored by Recep Erdem Ahan, Behide Saltepe and Onur Apayd\u0131n, Congrats!<\/p>\n

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    Our group member Sila K\u00f6se\u00a0\u00a0won Early Carrer Researcher Talk Award at the Designer Biology 2019 Conference . Congrats Sila !<\/p>\n

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    Ozge and Sila delivered talks on their works \u00a0at the Designer Biology 2019 conference at Newcastle organized by EFB Bioengineering and Bioprocessing Section.<\/p>\n

    http:\/\/designer-biology.org<\/a><\/p>\n

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    Dr. \u015eeker gave an invited talk at the GRC (Gordon Research Conferences) Synthetic Biology 2019 Meeting in Waterville Valley, NH, USA<\/p>\n

    https:\/\/www.grc.org\/synthetic-biology-conference\/2019\/<\/a><\/p>\n

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    SBL lab members attended 4th International Biosensor Congress organized by \u00c7anakkale Onsekiz Mart University. Dr \u015eeker delivered an invited talk on “Genetic Circuits Based Programming for Whole Cell Based Diagnosis”. Other groups members also delivered oral presentations :<\/p>\n

    S\u0131la K\u00f6se : “Cellular Biosensors with Engineered Genetic Logic Circuits for Biomedical Applications”<\/p>\n

    Nedim Haciosmano\u011flu: “A Theranostic Bio-Device for Type II Diabetes”<\/p>\n

    \u0130lkay \u00c7isil K\u00f6ksald\u0131 : “Heavy Metal Detection with Whole Cell Biosensors for Biomedical Applications”<\/p>\n

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    Dr. \u015eeker was interviewed by the Turkish Popular Science Journal T\u00dcB\u0130TAK Bilim Genc about Synthetic Biology, please follow the Youtube link (unfortunately only in Turkish :(( )<\/p>\n

    http:\/\/bilimgenc.tubitak.gov.tr\/makale\/sentetik-biyolojinin-biyomalzemelerde-kullanimi<\/a><\/p>\n